KRAS mutation in intrahepatic cholangiocarcinoma: Linkage with metastasis-free survival and reduced E-cadherin expression.
Mariko TanakaAkiko KunitaMakoto YamagishiHiroto KatohShumpei IshikawaHiroyuki YamamotoJun AbeJunichi AritaKiyoshi HasegawaTatsuhiro ShibataTetsuo UshikuPublished in: Liver international : official journal of the International Association for the Study of the Liver (2022)
Our observations suggest that KRAS mutations are associated with aggressive behaviour of ICC, especially the development of extrahepatic metastasis. Mutant KRAS is likely to change the adhesive status of ICC cells, affect the responsiveness of tumour cells to interferon immune signals, and consequently promote extrahepatic metastasis. KRAS mutation status, which predicts the prognoses of patients with ICC after surgical resection, is expected to help stratify patients better for individual postoperative treatment strategies.
Keyphrases
- wild type
- induced apoptosis
- free survival
- cell cycle arrest
- end stage renal disease
- ejection fraction
- chronic kidney disease
- newly diagnosed
- poor prognosis
- endoplasmic reticulum stress
- gene expression
- patients undergoing
- prognostic factors
- signaling pathway
- cell death
- dendritic cells
- genome wide
- binding protein
- pi k akt
- hepatitis c virus
- men who have sex with men