Histone demethylase KDM5 regulates cardiomyocyte maturation by promoting fatty acid oxidation, oxidative phosphorylation, and myofibrillar organization.

Manisha DeoghariaLeslye Venegas-ZamoraAkanksha Agrawal Miusi ShiAbhinav K JainKevin J McHugh Francisco AltamiranoAli J MarianPriyatansh Gurha

Published in: Cardiovascular research (2024)

KDM5 inhibition enhances maturation of iPSC-CMs by epigenetically upregulating the expressions of OXPHOS, FAO, and sarcomere genes and enhancing myofibril organization and mitochondrial function.

Keyphrases

fatty acid
dna methylation
genome wide
angiotensin ii
long noncoding rna
high glucose
induced pluripotent stem cells
endothelial cells
nitric oxide