Capecitabine induces hand-foot syndrome through elevated thymidine phosphorylase-mediated locoregional toxicity and GSDME-driven pyroptosis that can be relieved by tipiracil.
Bingxue YangXinran XieDazhao LvJiajun HuYuyun ChenZhaoyu WuShuyue LuoShiyi ZhangPublished in: British journal of cancer (2022)
Our findings reveal that the presence of elevated TP expression in the palm and sole aggravates local cell cytotoxicity, further explaining the molecular basis underlying 5-DFUR-induced cellular toxicity and providing a promising approach to the therapeutic management of HFS.