3-Amino-1,2,4-Triazole Induces Quick and Strong Fat Loss in Mice with High Fat-Induced Metabolic Syndrome.
Valéria Nunes-SouzaNelson Miguel Dias-JúniorMarcos Antônio Eleutério-SilvaVanessa P Ferreira-NevesFabiana Andréa MouraNatalia V AleninaMichael BaderLuiza Antas RabeloPublished in: Oxidative medicine and cellular longevity (2020)
In the context of HFD-induced obesity and metabolic syndrome, the fat loss induced by ATZ is probably due to heme synthesis inhibition, which blocks adipogenesis by probably decreased RevErbα activity, leading to apoptosis of adipocytes and the recruitment of macrophages. As a consequence of fat loss, ATZ elicits a beneficial systemic antiobesity effect and improves the metabolic status.