Malic Enzyme 1 Absence in Synovial Sarcoma Shifts Antioxidant System Dependence and Increases Sensitivity to Ferroptosis Induction with ACXT-3102.
Caitlyn B BrashearsBethany C PrudnerRicha RathoreKatharine E CaldwellCarina A DehnerJane L BuchananSara E S LangeNeal PoulinJennifer K SehnJason RoszikDirk SpitzerKevin B JonesRegis O'KeefeTorsten O NielsenEric B TaylorJason M HeldWilliam HawkinsBrian Andrew Van TinePublished in: Clinical cancer research : an official journal of the American Association for Cancer Research (2022)
These findings demonstrate the translational potential of targeting redox homeostasis in ME1-null cancers and establish the preclinical rationale for a phase I trial of ACXT-3102 in SS patients. See related commentary by Subbiah and Gan, p. 3408.