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Human CLEC9A antibodies deliver NY-ESO-1 antigen to CD141+ dendritic cells to activate naïve and memory NY-ESO-1-specific CD8+ T cells.

Kelly-Anne MastermanOscar L HaighKirsteen M TullettIngrid M Leal-RojasCarina WalpoleFrances E PearsonJonathon CebonChristopher SchmidtLiam O'BrienNikita RosendahlGhazal DarajIrina CaminschiEric H GschwengRoger P HollisDonald B KohnMireille H LahoudKristen J Radford
Published in: Journal for immunotherapy of cancer (2021)
These data advocate human CLEC9A-NY-ESO-1 Ab as an attractive strategy for specific targeting of CD141+ DCs to enhance tumor immunogenicity in NY-ESO-1-expressing malignancies.
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