Baseline Microglial Activation Correlates With Brain Amyloidosis and Longitudinal Cognitive Decline in Alzheimer Disease.
Qing WangGengsheng ChenSuzanne E SchindlerJon ChristensenNicole S McKayJingxia LiuSicheng WangZhexian SunJason HassenstabYi SuShaney FloresRuss C HornbeckLisa CashCarlos CruchagaAnne M FaganZhude TuJohn C MorrisMark A MintunYong WangTammie L S BenzingerPublished in: Neurology(R) neuroimmunology & neuroinflammation (2022)
This study provides Class II evidence that in patients with AD, higher baseline [11C]PK11195 SUVR averaged in the whole cortical regions was associated with longitudinal decline on cognitive tests.