Classification and characterization of alternative promoters in 26 lung adenocarcinoma cell lines.

Yamato HamayaAyako SuzukiYutaka SuzukiKatsuya Tsuchihara Riu Yamashita

Published in: Japanese journal of clinical oncology (2022)

Canonical promoters were regulated by conventional transcriptional machinery, while non-canonical promoters would be targets of 'leaky' expression. Further investigation is warranted to analyse the correlation between alternative promoter usage and biological characteristics contributing to carcinogenesis.

Keyphrases

transcription factor
gene expression
poor prognosis
machine learning
dna methylation
deep learning
binding protein
heat shock