Electrochemical Oxidative Regioselective C-H Cyanation of Imidazo[1,2-a]pyridines.

Electrochemical oxidative regioselective C-H cyanation of imidazo[1,2-a]pyridines was developed using readily available TMSCN as the cyano source. The KH2PO4/K2HPO4 buffer was essential for this transformation. This protocol was compatible with a broad range of substituted imidazo[1,2-a]pyridines and provided the C3 cyanated products in moderate to excellent yields.