Nose-to-brain delivery of sumatriptan-loaded nanostructured lipid carriers: preparation, optimization, characterization and pharmacokinetic evaluation.

Moein MasjediAmir AzadiReza HeidariSoliman Mohammadi Samani

Published in: The Journal of pharmacy and pharmacology (2020)

Neuropharmacokinetic evaluation of intranasal NLC dispersion represents a suitable brain delivery system. The DTP of NLC formulation suggests the desirable entrance of sumatriptan into the brain.

Keyphrases

resting state
white matter
drug delivery
functional connectivity
cerebral ischemia
multiple sclerosis
cancer therapy
fatty acid
mass spectrometry
wound healing
liquid chromatography