Cosmetic Results and Side Effects of Accelerated Partial-Breast Irradiation Versus Whole-Breast Irradiation for Low-Risk Invasive Carcinoma of the Breast: The Randomized Phase III IRMA Trial.
Bruno MeduriAntonella BaldisseraCinzia IottiLuc J E E ScheijmansMarcel R StamSalvatore ParisiLiesbeth J BoersmaIlario AmmendoliaEveline KoiterMariacarla ValliLuciano ScandolaroDianne BuszMarika C Stenfert KroeseSelena CiabattiPatrizia GiacobazziMaria P RuggieriAntoine EngelenTindara MunafòA Helen WestenbergKarolien VerhoevenRoberto ViciniRoberto D'AmicoFrank LohrFilippo BertoniPhilip M P PoortmansGiovanni P FrezzaPublished in: Journal of clinical oncology : official journal of the American Society of Clinical Oncology (2023)
External beam radiation therapy-APBI with a twice-daily IRMA schedule was associated with increased rates of late moderate soft tissue and bone toxicities, with a slight decrease in patient-reported cosmetic outcomes at 5 years when compared with WBI, although overall toxicity was in an acceptable range.
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