Should androgen deprivation therapy and other systemic treatments be used in men with prostate cancer and a rising PSA post-local treatments?
Anna PatrikidouThomas ZilliGiulia BaciarelloSafae TerisseZineb HamilouKarim FizaziPublished in: Therapeutic advances in medical oncology (2021)
Biochemical recurrence is an evolving space in prostate cancer, with increasing multidisciplinary involvement. Androgen deprivation therapy has shown proof of its value in complementing salvage radiotherapy in high-risk biochemical relapsing patients; ongoing trials aim to further refine this treatment combination. As systemic treatments, and notably next-generation androgen receptor targeted agents, have moved towards early hormone-sensitive and non-metastatic stages, the prostate specific antigen (PSA)-relapse disease stage will be undoubtedly challenged by future evidence from such ongoing clinical trials. With the use of modern imaging and newer molecular technologies, including integration of tumoral genomic profiling and liquid biopsies in risk stratification, a path towards a precision oncology-focused approach will become a reality to guide in the future decisions for patients with a diagnosis of biochemical recurrence.
Keyphrases
- prostate cancer
- radical prostatectomy
- clinical trial
- end stage renal disease
- free survival
- ejection fraction
- current status
- chronic kidney disease
- multiple sclerosis
- squamous cell carcinoma
- newly diagnosed
- early stage
- small cell lung cancer
- radiation therapy
- high resolution
- palliative care
- gene expression
- copy number
- prognostic factors
- combination therapy
- mass spectrometry
- locally advanced
- systemic lupus erythematosus
- radiation induced
- genome wide
- quality improvement
- randomized controlled trial
- double blind