Risk factors for cardiovascular disease in primary Sjögren's syndrome (pSS): a 20-year follow-up study.
Cristiana Sieiro SantosRuben Rego SalgueiroClara Moriano MoralesCarolina Álvarez CastroElvira Díez ÁlvarezPublished in: Clinical rheumatology (2023)
Extraglandular involvement was associated with a higher prevalence of arterial hypertension, dyslipidemia, hyperuricemia, and coronary artery disease. Anti-Ro/SSA and anti-La/SSB seropositivity was associated with a higher prevalence of cardiac rhythm abnormalities, hyperuricemia, venous thrombosis, coronary artery disease, and cerebrovascular disease. Raised inflammatory markers, disease activity measured by ESSDAI, extraglandular involvement, serologic markers including hypergammaglobulinemia and low C3, and treatment with corticosteroids were associated with a higher risk for cardiovascular comorbidities. Key Points • Patients with pSS are vulnerable to cardiovascular risk factors. There is an interconnection between extraglandular involvement, disease activity, inflammatory markers, and cardiovascular risk comorbidities. • Anti-Ro/SSA and anti-La/SSB seropositivity was associated with a higher frequency of cardiac conduction abnormalities, coronary artery disease, venous thrombosis, and stroke. • Hypergammaglobulinemia, elevated ESR, and low C3 are associated with a higher prevalence of cardiovascular comorbidities. • Valid risk stratification tools to help with prevention and consensus on the management of CVDs in pSS patients are warranted.
Keyphrases
- disease activity
- coronary artery disease
- rheumatoid arthritis
- systemic lupus erythematosus
- cardiovascular risk factors
- rheumatoid arthritis patients
- cardiovascular disease
- ankylosing spondylitis
- risk factors
- juvenile idiopathic arthritis
- cardiovascular events
- percutaneous coronary intervention
- left ventricular
- atrial fibrillation
- arterial hypertension
- uric acid
- metabolic syndrome
- end stage renal disease
- newly diagnosed
- ejection fraction
- type diabetes
- case report
- sars cov
- blood pressure
- clinical practice
- blood brain barrier
- patient reported outcomes
- cerebral ischemia
- replacement therapy
- respiratory syndrome coronavirus