Early limbic microstructural alterations in apathy and depression in de novo Parkinson's disease.

Stéphane PrangeElise MetereauAudrey MailletEugénie LhomméeHélène KlingerPierre PelissierDanielle IbarrolaRolf A HeckemannAnna CastriotoLéon TremblayVéronique SgambatoEmmanuel BroussollePaul KrackStéphane Thobois

Published in: Movement disorders : official journal of the Movement Disorder Society (2019)

Early limbic microstructural alterations specifically related to apathy and depression emphasize the role of early disruption of ascending nondopaminergic projections and related corticocortical and corticosubcortical networks which underpin the variable expression of nonmotor and neuropsychiatric symptoms in Parkinson's disease. © 2019 International Parkinson and Movement Disorder Society.

Keyphrases

depressive symptoms
sleep quality
poor prognosis
white matter
multiple sclerosis
long non coding rna
pulmonary artery
coronary artery
drug induced
aortic dissection