Estrogen as a guardian of auditory health: Tsp1-CD47 axis regulation and noise-induced hearing loss.
Xiaoxue WangH ZhengB YangM ZuZ WangJ ZhangF ZhengM YangMichael Chi-Fai TongL ZhaoWen-Pei BaiPublished in: Climacteric : the journal of the International Menopause Society (2023)
OVX rats were more susceptible to NIHL, and the protective effect of estrogen was achieved through regulation of the Tsp1-CD47 axis. This study presents a novel mechanism through which estrogen regulates NIHL and offers a potential intervention strategy for the clinical treatment of NIHL.