MiR-21-5p regulates the dynamic of mitochondria network and rejuvenates the senile phenotype of bone marrow stromal cells (BMSCs) isolated from osteoporotic SAM/P6 mice.
Mateusz SikoraAgnieszka ŚmieszekAriadna PielokKrzysztof MaryczPublished in: Stem cell research & therapy (2023)
Our results demonstrate that miR-21-5p regulates the fission and fusion processes of mitochondria and facilitates the stemness restoration of senile osteoporotic BMSCs. At the same time, it enhances the expression of RUNX-2, while reduces TRAP accumulation in the cells with deteriorated phenotype. Therefore, miR-21-5p may bring a novel molecular strategy for senile osteoporosis diagnostics and treatment.
Keyphrases
- bone mineral density
- bone marrow
- cell death
- cell cycle arrest
- induced apoptosis
- postmenopausal women
- stem cells
- poor prognosis
- mesenchymal stem cells
- reactive oxygen species
- endoplasmic reticulum
- transcription factor
- body composition
- high fat diet induced
- endoplasmic reticulum stress
- signaling pathway
- oxidative stress
- single molecule
- skeletal muscle
- wild type