Acquired CFTR dysfunction and dense distribution of ionocytes in nasal mucosa of children with CRS.

Yang HanChao JiaTieshan WangPengpeng WangWenjing LiuYu QinSiyu CaiXiaojian YangWei ZhangYuwei LiuXiao XiaoLejian HeWentong GeXin Ni

Published in: European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery (2023)

The number of ionocytes and the function of CFTR in nasal mucosa of CRS patients decreased. With the expansion of inflammation, CFTR and ionocytes showed more obvious dense distribution. Some ionocytes lost the expression of CFTR and did not show the "tadpole" shape, which may be related to the occurrence of polyps.

Keyphrases

cystic fibrosis
chronic rhinosinusitis
end stage renal disease
oxidative stress
ejection fraction
newly diagnosed
chronic kidney disease
poor prognosis
risk assessment
young adults
peritoneal dialysis
long non coding rna
binding protein