The effectiveness of ketamine on anxiety, irritability, and agitation: Implications for treating mixed features in adults with major depressive or bipolar disorder.

Roger S McIntyre Orly LipsitzNelson B RodriguesYena LeeDanielle S ChaMaj VinbergKangguang LinGin S MalhiMehala SubramaniapillaiKevin KratiukAndrea FagioliniHartej GillFlora NasriRodrigo B MansurTrisha SuppesRoger HoJoshua D Rosenblat

Published in: Bipolar disorders (2020)

Our preliminary results suggest that IV ketamine is effective in rapidly treating AIA and SI in adults with treatment-resistant mood disorders. This observation suggests that IV ketamine could be considered a treatment alternative for adults with MDD or BD presenting with mixed features.

Keyphrases

bipolar disorder
major depressive disorder
pain management
randomized controlled trial
systematic review
sleep quality
chronic pain
depressive symptoms
stress induced