Impact of geography on prognostic outcomes of 21,509 patients with metastatic colorectal cancer enrolled in clinical trials: an ARCAD database analysis.
Jun YinShaheenah DawoodRomain CohenJeff MeyersJohn ZalcbergTakayuki YoshinoMatthew SeymourTim MaughanLeonard SaltzEric Van CutsemAlan VenookHans-Joachim SchmollRichard GoldbergPaulo HoffJ Randolph HechtHerbert HurwitzCornelis PuntEduard Diaz RubioMiriam KoopmanChiara CremoliniVolker HeinemannChristophe TournigardCarsten BokemeyerCharles FuchsNiall TebbuttJohn SouglakosJean-Yves DoulliardFairooz KabbinavarBenoist ChibaudelAimery de GramontQian ShiAxel GrotheyRichard A AdamsPublished in: Therapeutic advances in medical oncology (2021)
Significant international disparities in the OS of cohorts of mCRC patients enrolled in RCTs were found. Survival of mCRC patients included in RCTs was consistently lower in the UK and Ireland regions than in central Europe, southern Europe, and the USA, potentially attributed to greater overall population representation, delayed diagnosis, and reduced availability of therapies.