PSMD1 and PSMD2 regulate HepG2 cell proliferation and apoptosis via modulating cellular lipid droplet metabolism.

Yanjie TanYi JinXiang WuZhuqing Ren

Published in: BMC molecular biology (2019)

We demonstrate that PSMD1 and PSMD2 promote the proliferation of HepG2 cells via facilitating cellular lipid droplet accumulation. This study provides a potential therapeutic strategy for the treatment of lipid-rich tumors.

Keyphrases

cell proliferation
fatty acid
signaling pathway
high throughput
single cell
oxidative stress
endoplasmic reticulum stress
cell death
cell cycle
cell cycle arrest