Investigating receptor-mediated antibody transcytosis using blood-brain barrier organoid arrays.

Claire SimonneauMartina DuschmaléAlina GavrilovNathalie BrandenbergSylke HoehnelCamilla CeroniEvodie LassalleElena KassianidouHendrik KnoetgenJens NiewoehnerRoberto Villaseñor

Published in: Fluids and barriers of the CNS (2021)

Human BBB organoid arrays are a robust high-throughput platform that can be used to discover new mechanisms of receptor-mediated antibody transcytosis. The implementation of this platform during early stages of drug discovery can accelerate the development of new brain delivery technologies.

Keyphrases

blood brain barrier
high throughput
drug discovery
cerebral ischemia
endothelial cells
single cell
high density
primary care
resting state
induced pluripotent stem cells
white matter
quality improvement
pluripotent stem cells
functional connectivity