Transcriptional consequences of MBD5 disruption in mouse brain and CRISPR-derived neurons.

Catarina M SeabraTatsiana AneichykSerkan ErdinDerek J C TaiCeline E F De EschParisa RazazYu AnPoornima ManavalanAshok RagavendranAlexei StortchevoiClemer AbadJuan I YoungPatricia MacielMichael E TalkowskiJames F Gusella

Published in: Molecular autism (2020)

Our study points to modest and context-dependent transcriptional consequences of Mbd5 disruption in the brain. It also suggests a possible link between MBD5 and perturbations in ciliary function, which is an established pathogenic mechanism in developmental disorders and syndromes.

Keyphrases

gene expression
transcription factor
crispr cas
genome wide
genome editing
white matter
resting state
heat shock
multiple sclerosis
spinal cord injury
cerebral ischemia
functional connectivity
subarachnoid hemorrhage
brain injury