SCD1 activity promotes cell migration via a PLD-mTOR pathway in the MDA-MB-231 triple-negative breast cancer cell line.

Marine LingrandSimon LalondeAntoine Jutras-CarignanKarl-Frédérik BergeronEric RassartCatherine Mounier

Published in: Breast cancer (Tokyo, Japan) (2020)

Our results establish a key role for the lipid desaturase SCD1 and delineate an OA-PLD-mTOR/p70S6K signaling pathway in TNBC-derived MDA-MB-231 cell migration.

Keyphrases

cell migration
breast cancer cells
signaling pathway
cell proliferation
pi k akt
cell cycle arrest
epithelial mesenchymal transition
fatty acid
induced apoptosis
cell death
oxidative stress
endoplasmic reticulum stress