METTL14-mediated N 6 -methyladenosine modification of ITGB4 mRNA inhibits metastasis of clear cell renal cell carcinoma.

Zhuonan LiuTianshui SunChiyuan PiaoZhe ZhangChui-Ze Kong

Published in: Cell communication and signaling : CCS (2022)

Our study reveals that METTL14 inhibits ITGB4 expression via m6A modification to attenuate metastasis and EMT of ccRCC cells, suggesting the METTL14/ITGB4 axis as a potential prognostic biomarker and therapeutic target for ccRCC. Video Abstract.

Keyphrases

induced apoptosis
poor prognosis
binding protein
epithelial mesenchymal transition
cell cycle arrest
signaling pathway
oxidative stress
long non coding rna