Catalyst-Free α-Alkylation-α-Hydroxylation of Oxindole with Alcohols.
Siwei WuWei SongRunyu ZhuJingwen HuLin ZhaoZheyao LiXinhong YuCheng-Cai XiaJianhong ZhaoPublished in: The Journal of organic chemistry (2022)
3-Alkyl-3-hydroxyoxindoles, a subclass of oxindole products, have antioxidant, neuroprotective, anticancer, and anti-HIV activities. In this study, a green and economical protocol for the synthesis of 3-alkyl-3-hydroxyoxindoles is developed for the first time via α-alkylation-α-hydroxylation of oxindole with benzyl alcohols without using any transition-metal catalysts in yields of 29-93%.
Keyphrases
- transition metal
- ionic liquid
- highly efficient
- antiretroviral therapy
- hiv infected
- hiv positive
- human immunodeficiency virus
- randomized controlled trial
- hepatitis c virus
- hiv testing
- oxidative stress
- visible light
- room temperature
- hiv aids
- men who have sex with men
- brain injury
- carbon dioxide
- subarachnoid hemorrhage