Deep Brain Stimulation for Alzheimer's Disease: Tackling Circuit Dysfunction.

Jordan Lewis William LamJustin LeeCharles Y LiuAndres M LozanoDarrin J Lee

Published in: Neuromodulation : journal of the International Neuromodulation Society (2020)

DBS is an intriguing potential treatment for Alzheimer's disease, targeting circuit dysfunction as a novel therapeutic target. However, further exploration of the basic disease pathology and underlying mechanisms of DBS is necessary to better understand how circuit dysfunction can be restored. Additionally, robust clinical data in the form of ongoing phase III clinical trials are needed to validate the efficacy of DBS as a viable treatment.

Keyphrases

deep brain stimulation
parkinson disease
clinical trial
phase iii
obsessive compulsive disorder
oxidative stress
open label
cognitive decline
randomized controlled trial
phase ii
machine learning
cancer therapy
risk assessment
big data
replacement therapy