CIQ, a positive allosteric modulator of GluN2C/D-containing N-methyl-d-aspartate receptors, rescues striatal synaptic plasticity deficit in a mouse model of Parkinson's disease.

Mona NouhiXiaoqun ZhangNing YaoKarima Chergui

Published in: CNS neuroscience & therapeutics (2017)

A positive allosteric modulator of GluN2C/D-containing NMDARs rescues LTP and forelimb-use asymmetry in a mouse model of PD. This study proposes GluN2D as a potential candidate for therapeutic intervention in PD.

Keyphrases

mouse model
small molecule
randomized controlled trial
parkinson disease
functional connectivity
risk assessment
human health
climate change
deep brain stimulation