Ayurvedic treatment induced severe alcoholic hepatitis and non-cirrhotic portal hypertension in a 14-year-old girl.
Cyriac Abby PhilipsRizwan AhamedJinsha K AbduljaleelSasidharan RajeshArif Hussain TheruvathResmi RaveendranPhilip AugustinePublished in: Oxford medical case reports (2022)
We report a novel and as yet undescribed clinical scenario in a young girl with liver failure, in whom, the liver histopathology was suggestive of alcoholic hepatitis in the background of hepatoportal sclerosis and incomplete septal cirrhosis. An extensive clinical and investigational evaluation revealed chronic consumption of multiple Ayurvedic herbal medications for seizure disease. Six months after stopping herbal medicines, the repeat liver biopsy demonstrated resolution of alcohol-related changes but persistence of classical features of non-cirrhotic portal hypertension. Analysis of the retrieved agents, including state of the art chemical and toxicology analysis, using gas chromatography and mass spectroscopy methods demonstrated multiple organic and inorganic toxins associated with acute alcohol and arsenic poisoning related hepatoportal sclerosis/incomplete septal cirrhosis in the young girl.
Keyphrases
- liver failure
- drug induced
- liver injury
- gas chromatography
- blood pressure
- hepatitis b virus
- mass spectrometry
- single molecule
- tandem mass spectrometry
- temporal lobe epilepsy
- hypertrophic cardiomyopathy
- middle aged
- drinking water
- high resolution
- heavy metals
- high glucose
- randomized controlled trial
- gas chromatography mass spectrometry
- heart failure
- diabetic rats
- high resolution mass spectrometry
- respiratory failure
- ultrasound guided