Involvement of dysregulated hippocampal histone H3K9 methylation at the promoter of the BDNF gene in impaired memory extinction.

Kenichi OgaManabu FuchikamiHironori KobayashiTatsuhiro MiyagiSho FujitaSatoshi FujitaSatoshi OkadaShigeru Morinobu

Published in: Psychopharmacology (2024)

We conclude that reduced hippocampal levels of BDNF mRNA due to increase in H3K9me2 levels may play a role in PTSD-associated EFM impairment, and BIX01294 could be a PTSD treatment option.

Keyphrases

dna methylation
genome wide
posttraumatic stress disorder
social support
stress induced
gene expression
copy number
transcription factor
binding protein
depressive symptoms
brain injury