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Profiling of patient-specific myocytes identifies altered gene expression in the ophthalmoplegic subphenotype of myasthenia gravis.

Melissa NelSharon PrinceJeannine M Heckmann
Published in: Orphanet journal of rare diseases (2019)
Using a surrogate cell culture model our findings suggest that muscle gene expression and co-expression differ between OP-MG and control MG individuals. These findings implicate pathways not previously considered in extraocular muscle involvement in myasthenia gravis and will inform future studies.
Keyphrases
  • myasthenia gravis
  • gene expression
  • skeletal muscle
  • dna methylation
  • poor prognosis
  • binding protein
  • case control