Transcriptome analysis reveals the essential role of NK2 homeobox 1/thyroid transcription factor 1 (NKX2-1/TTF-1) in gastric adenocarcinoma of fundic-gland type.

Kazushi FukagawaYu TakahashiNobutake YamamichiNatsuko Kageyama-YaharaYoshiki SakaguchiMiho ObataRina ChoNobuyuki SakumaSayaka NagaoYuko MiuraNaoki TamuraDaisuke OhkiHiroya MizutaniSeiichi YakabiChihiro MinatsukiKeiko NiimiYosuke TsujiMitsue YamamichiNarumi ShigiShuta TomidaHiroyuki AbeTetsuo UshikuKazuhiko KoikeMitsuhiro Fujishiro

Published in: Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association (2022)

Our first transcriptome analysis of GA-FG indicates significant expression of NKX2-1/TTF1 in GA-FG. Immunohistochemistry and cell biology show ectopic expression and normal transactivation ability of NKX2-1/TTF-1, suggesting that it plays an essential role in GA-FG development.

Keyphrases

pet ct
poor prognosis
transcription factor
single cell
squamous cell carcinoma
binding protein
gene expression
rna seq
cell therapy
long non coding rna
dna methylation
dna binding