Efficacy and safety of avatrombopag in combination with immunosuppressive therapy in treatment-naïve and relapsed/refractory severe aplastic anaemia: protocol for the DIAAMOND-Ava-FIRST and DIAAMOND-Ava-NEXT Bayesian Optimal Phase II trials.

Zoe K McQuiltenStephane HeritierLucy FoxVanessa FoxLauren YoungPiers BlomberyIlona CunninghamJennifer CurnowAlisa HigginsDevendra K HiwaseRobin FilshieFrank FirkinPaul LacazeKylie MasonAnthony K MillsDominic PepperellSushrut PatilWilliam StevensonJeff SzerNeil WatersKate WilsonStephen TingErica Wood

Published in: BMJ open (2024)

ACTRN12619001042134, ACTRN12619001043123.

Keyphrases

phase ii
clinical trial
open label
acute lymphoblastic leukemia
acute myeloid leukemia
randomized controlled trial
diffuse large b cell lymphoma
multiple myeloma
allogeneic hematopoietic stem cell transplantation
early onset
hodgkin lymphoma
phase iii
double blind
combination therapy
drug induced