Practical guidance for running late-phase platform protocols for clinical trials: lessons from experienced UK clinical trials units.

Sharon B LoveFay CaffertyClaire SnowdonKaren CartyJoshua SavagePhilip PallmannLucy McParlandLouise BrownLindsey MastersFrancesca SchiavoneDominic HagueStephen TownsendClaire AmosAnnabelle SouthKate SturgeonRuth LangleyTimothy MaughanNicholas JamesEmma HallSarah KernaghanJudith BlissNick TurnerAndrew TuttChristina YapCharlotte FirthAnthony KongHisham MehannaColin WattsRobert HillsIan ThomasMhairi CoplandSue BellDavid Sebag-MontefioreRobert JonesMahesh K B ParmarMatthew R Sydes

Published in: Trials (2022)

Platform protocols enable many questions to be answered efficiently to the benefit of patients. Our practical lessons from running platform trials will support trial teams in learning how to run these trials more effectively and efficiently.

Keyphrases

clinical trial
high throughput
end stage renal disease
phase ii
phase iii
high intensity
chronic kidney disease
study protocol
prognostic factors
randomized controlled trial
patient reported