Methotrexate and low-dose prednisolone downregulate osteoclast function by decreasing receptor activator of nuclear factor-κβ expression in monocytes from patients with early rheumatoid arthritis.

Inês Pedro PerpétuoJoana Caetano-LopesAna Maria RodriguesRaquel Campanilho-MarquesCristina PonteHelena CanhãoMari AinolaJoão Eurico Fonseca

Published in: RMD open (2017)

Our results suggest that MTX+PDN play an important role in downregulating OC function, which we believe occurs through the decrease in RANK surface expression in monocytes.

Keyphrases

nuclear factor
low dose
poor prognosis
rheumatoid arthritis
toll like receptor
binding protein
dendritic cells
peripheral blood
immune response
disease activity
inflammatory response
interstitial lung disease
idiopathic pulmonary fibrosis
bone loss