Methotrexate and low-dose prednisolone downregulate osteoclast function by decreasing receptor activator of nuclear factor-κβ expression in monocytes from patients with early rheumatoid arthritis.
Inês Pedro PerpétuoJoana Caetano-LopesAna Maria RodriguesRaquel Campanilho-MarquesCristina PonteHelena CanhãoMari AinolaJoão Eurico FonsecaPublished in: RMD open (2017)
Our results suggest that MTX+PDN play an important role in downregulating OC function, which we believe occurs through the decrease in RANK surface expression in monocytes.