Increased CD69+CCR7+ circulating activated T cells and STAT3 expression in cutaneous lupus erythematosus patients recalcitrant to antimalarials.
Majid ZeidiKristen L ChenJay R PatelKrisha DesaiHee Joo KimSrita ChakkaRachel LimVictoria P WerthPublished in: Lupus (2022)
An increased number of CD69+CCR7+ circulating activated T cells and a strong correlation with CLASI scores in the HCQ+QC-nonresponders suggest these cells are involved in antimalarial-refractory skin disease. STAT3 is also increased in HCQ+QC-nonresponders and may also be a potential target for antimalarial-refractory skin disease.
Keyphrases
- end stage renal disease
- induced apoptosis
- ejection fraction
- cell proliferation
- chronic kidney disease
- dendritic cells
- newly diagnosed
- poor prognosis
- regulatory t cells
- soft tissue
- peritoneal dialysis
- plasmodium falciparum
- nk cells
- oxidative stress
- patient reported outcomes
- immune response
- climate change
- binding protein
- patient reported