The 2023 Orthopaedic Research Society's International Consensus Meeting on Musculoskeletal Infection: Summary from the In Vitro Section.
Noreen J HickokBingyun LiEbru OralSebastian A J ZaatDavid A ArmbrusterGerald J AtkinsAntonia F ChenDébora Cristina Coraça-HuberTianhong DaiEdward M GreenfieldRajendra KasinathMatthew LiberaCláudia N H MarquesThomas Fintan MoriartyK Scott PhillipsKapil RaghuramanDacheng RenLia RimondiniKordo SaaedThomas P SchaerEdward M SchwarzChristopher SpiegelPaul StoodleyVi Khanh TruongShao-Ting Jerry TsangBritt WildemannAnja R ZelmerAnnelies S ZinkernagelPublished in: Journal of orthopaedic research : official publication of the Orthopaedic Research Society (2023)
Antimicrobial strategies for musculoskeletal infections are typically first developed with in vitro models. The In Vitro Section of the 2023 Orthopaedic Research Society Musculoskeletal Infection (ORS MSKI) international consensus meeting (ICM) probed our state of knowledge of in vitro systems with respect to bacteria and biofilm phenotype, standards, in vitro activity, and the ability to predict in vivo efficacy. A subset of ICM delegates performed systematic reviews on 15 questions and made recommendations and assessment of the level of evidence that were then voted on by 72 ICM delegates. Here we report recommendations and rationale from the reviews and the results of the internet vote. Only 2 questions received a >90% consensus vote, emphasizing the disparate approaches and lack of established consensus for in vitro modeling and interpretation of results. Comments on knowledge gaps and the need for further research on these critical MSKI questions are included. This article is protected by copyright. All rights reserved.