Characterization and Clinical Outcomes of DNA Mismatch Repair-deficient Small Bowel Adenocarcinoma.
Alicia J LathamJinru ShiaZalak PatelDiane L Reidy-LagunesNeil H SegalRona YaegerKaruna GaneshLouise ConnellNancy E KemenyDavid P KelsenJaclyn F HechtmanGarrett M NashPhilip B PatyAhmet ZehirKaitlin A TkachukRania SheikhArnold J MarkowitzDiana MandelkerKenneth OffitMichael F BergerAndrea CercekJulio Garcia-AguilarLeonard B SaltzMartin R WeiserZsofia K StadlerPublished in: Clinical cancer research : an official journal of the American Association for Cancer Research (2020)
When compared with MMR-P SBA, MMR-D SBA was associated with earlier stage disease and lower recurrence rates, similar to observations in colorectal cancer. With a 38.5% prevalence in MMR-D SBA, germline Lynch syndrome testing in MMR-D SBA is warranted.