Preventing Early Renal Loss in Diabetes (PERL) Study: A Randomized Double-Blinded Trial of Allopurinol-Rationale, Design, and Baseline Data.
Maryam AfkarianSarit PolskyAfshin ParsaRonnie AronsonMaria Luiza CaramoriDavid Z I CherneyJill P CrandallIan H de BoerThomas G ElliottAndrzej T GaleckiAllison B GoldfineJ Sonya HawIrl B HirschAmy B KargerIldiko LingvayDavid M MaahsJanet B McGillMark E MolitchBruce A PerkinsPradipta R RayMarlon PragnellSylvia E RosasPeter RossingPeter SeniorRonald J SigalCatherine SpinoKatherine R TuttleGuillermo E UmpierrezAmisha WalliaRuth S WeinstockChunyi WuMichael MauerAlessandro Dorianull nullPublished in: Diabetes care (2019)
PERL will determine the effect of allopurinol on mild to moderate DKD in T1D, with or without albuminuria. Participants with normoalbuminuria and rapid GFR loss manifested many DKD risk factors of those with albuminuria, but with less severity.