Anti-inflammatory and immunomodulatory effects of Lactobacillus spp. as a preservative and therapeutic agent for IBD control.

Shadi AghamohammadAmin SepehrSeyedeh Tina MiriSaeideh NajafiMohammad R PourshafieMahdi Rohani

Published in: Immunity, inflammation and disease (2022)

Our Lactobacillus spp. cocktail showed anti-inflammatory effects on HT-29 cells by modulating JAK/STAT and NF-κB signaling pathways in all three treatment variants. Therefore, Lactobacillus spp. as a dietary supplement can both prevent and reduce inflammation-related diseases such as inflammatory bowel disease.

Keyphrases

anti inflammatory
signaling pathway
induced apoptosis
oxidative stress
pi k akt
cell cycle arrest
lactic acid
epithelial mesenchymal transition
copy number
endoplasmic reticulum stress
immune response
combination therapy
gene expression
dna methylation
replacement therapy
drug induced