The Effect of Sialic Acid on MiR-320a and Let-7e Expression in Human Glial Cell Line.

Inflammation in the nervous system occurs because of numerous factors. Sialic acid is an inflammatory factor that promotes cellular inflammation, particularly in the glial cells. That is why it could serve as a useful model for simulating several neurodegenerative diseases, including Parkinson's and Multiple sclerosis. Changes in sialic acid concentration are observed in many pathological states, which could be a useful marker for identifying the inflammatory process. The present study was carried out to examine the impact of different concentrations of sialic acid on two non-coding RNAs in glial cells. Our research shows that these two microRNAs greatly increased when responding to sialic acid. We suggest that these two microRNAs are contributed to the neuroinflammatory pathways related to sialic acid.