Dorsolateral Prefrontal Cortex GABA Concentration in Humans Predicts Working Memory Load Processing Capacity.
Jong H YoonAnthony GrandelisRichard J MaddockPublished in: The Journal of neuroscience : the official journal of the Society for Neuroscience (2017)
This study demonstrated for the first time that the amount of gamma-aminobutryic acid (GABA), the major inhibitory neurotransmitter of the brain, in an individual's prefrontal cortex predicts working memory (WM) task performance. Given that WM is required for many of the most characteristic cognitive and behavioral capabilities in humans, this finding could have a significant impact on our understanding of the neural basis of complex human behavior. Furthermore, this finding suggests that efforts to preserve or increase brain GABA levels could be fruitful in remediating WM-related deficits associated with neuropsychiatric conditions.
Keyphrases
- working memory
- prefrontal cortex
- resting state
- transcranial direct current stimulation
- white matter
- attention deficit hyperactivity disorder
- endothelial cells
- functional connectivity
- traumatic brain injury
- induced pluripotent stem cells
- quality improvement
- multiple sclerosis
- pluripotent stem cells
- high frequency