Polymer-free stents for percutaneous coronary intervention in diabetic patients: a systematic review and meta-analysis.
Filippo Luca GurgoglioneDavide DonelliMichele AntonelliLuigi VignaliGiorgio BenattiEmilia SolinasIacopo TadonioGiulia MagnaniAndrea DenegriDavide LazzeroniRocco Antonio MontoneRiccardo C BonadonnaFrancesco NicoliniDiego ArdissinoGiampaolo NiccoliPublished in: Future cardiology (2024)
Aim: To compare the efficacy of polymer-free drug-eluting stents (PF-DES) versus other stents in diabetic patients with coronary artery disease undergoing percutaneous coronary interventions. Materials & methods: A systematic review and meta-analysis were performed to identify pertinent randomized controlled trials. The primary end point was the occurrence of target lesion failure. Results: Eight randomized controlled trials were included for a total of 4854 subjects. The PF-DES group experienced a trend in favor of a lower rate of target lesion failure (Incidence rate ratio = 0.91; p = 0.11) and a significantly lower rate of cardiac mortality, as compared with the control group (Incidence rate ratio = 0.82; p = 0.04). However, statistical significance was lost if bare-metal stent patients were excluded and a trend in favor of the PF-DES strategy was reported only for cardiac mortality. Conclusion: PF-DES could be a valuable strategy in diabetic patients with coronary artery disease undergoing percutaneous coronary interventions.
Keyphrases
- coronary artery disease
- randomized controlled trial
- risk factors
- percutaneous coronary intervention
- coronary artery
- cardiovascular events
- type diabetes
- end stage renal disease
- left ventricular
- ejection fraction
- physical activity
- minimally invasive
- acute coronary syndrome
- ultrasound guided
- risk assessment
- acute myocardial infarction
- peritoneal dialysis
- aortic stenosis
- systematic review
- atrial fibrillation
- coronary artery bypass grafting
- radiofrequency ablation
- cardiovascular disease
- heart failure
- emergency department
- patient reported outcomes
- antiplatelet therapy
- study protocol
- patient reported
- transcatheter aortic valve replacement
- electronic health record
- coronary artery bypass