A long-term prognosis study of human USP8-mutated ACTH-secreting pituitary neuroendocrine tumours.

Hui MiaoLuo WangFengying GongLian DuanLinjie WangYong YaoMing FengKan DengRenzhi WangYu XiaoQing LingHui-Juan ZhuLin Lu

Published in: Clinical endocrinology (2024)

Somatic USP8 variants accounted for 50% of the genetic causes in this cohort with a significant female frequency. A long-term follow-up revealed a tendency toward shorter recurrence-free survival in USP8-mutant patients.

Keyphrases

free survival
copy number
end stage renal disease
endothelial cells
newly diagnosed
chronic kidney disease
ejection fraction
prognostic factors
genome wide
single cell
gene expression
dna methylation
pluripotent stem cells