How I treat recurrent pediatric high-grade glioma (pHGG): a Europe-wide survey study.

Thomas PerweinBarbara GieseGunther NussbaumerAndré O von BuerenMiriam van BuirenMartin BeneschChristof Maria Kramm

Published in: Journal of neuro-oncology (2023)

In each case, experts would combine conventional multimodal treatment concepts, including re-irradiation, with targeted therapy based on molecular genetic findings. International cooperative trials combining a (chemo-)therapy backbone with targeted therapy approaches for defined subgroups may help to gain valid clinical data and improve treatment in pediatric patients with recurrent/progressing HGG.

Keyphrases

high grade
combination therapy
gene expression
low grade
cross sectional
genome wide
drug delivery
mesenchymal stem cells
pain management
chronic pain
single molecule
childhood cancer