Depletion of Conventional Type-1 Dendritic Cells in Established Tumors Suppresses Immunotherapy Efficacy.

Alvaro Teijeira Saray Garasa Carlos Luri-Rey Carlos E De Andrea Maria Gato-Cañas Carmen Molina Tsuneyasu Kaisho Assunta Cirella Arantza Azpilikueta Steffanie K Wculek Josune Egea Irene Olivera Inmaculada Rodriguez Ana Rouzaut Vladislav V Verkhusha Karmele Valencia David Sancho Pedro Berraondo Ignacio Melero Bermejo

Published in: Cancer research (2022)

These findings reveal the intratumoral behavior of cDC1 dendritic cells in transgenic mouse models and demonstrate that the efficacy of immunotherapy regimens is precluded by elimination of these cells.

Keyphrases

dendritic cells
immune response
regulatory t cells
induced apoptosis
mouse model
cell cycle arrest
signaling pathway
single cell
cell cycle
endoplasmic reticulum stress
cell death