Nicotinamide mononucleotide increases muscle insulin sensitivity in prediabetic women.
Mihoko YoshinoJun YoshinoBrandon D KayserGary J PattiMichael P FranczykKathryn F MillsMiriam SindelarTerri A PietkaBruce W PattersonShin-Ichiro ImaiSamuel KleinPublished in: Science (New York, N.Y.) (2021)
In rodents, obesity and aging impair nicotinamide adenine dinucleotide (NAD+) biosynthesis, which contributes to metabolic dysfunction. Nicotinamide mononucleotide (NMN) availability is a rate-limiting factor in mammalian NAD+ biosynthesis. We conducted a 10-week, randomized, placebo-controlled, double-blind trial to evaluate the effect of NMN supplementation on metabolic function in postmenopausal women with prediabetes who were overweight or obese. Insulin-stimulated glucose disposal, assessed by using the hyperinsulinemic-euglycemic clamp, and skeletal muscle insulin signaling [phosphorylation of protein kinase AKT and mechanistic target of rapamycin (mTOR)] increased after NMN supplementation but did not change after placebo treatment. NMN supplementation up-regulated the expression of platelet-derived growth factor receptor β and other genes related to muscle remodeling. These results demonstrate that NMN increases muscle insulin sensitivity, insulin signaling, and remodeling in women with prediabetes who are overweight or obese (clinicaltrial.gov NCT03151239).
Keyphrases
- placebo controlled
- double blind
- skeletal muscle
- type diabetes
- weight loss
- phase iii
- growth factor
- phase ii
- glycemic control
- clinical trial
- insulin resistance
- study protocol
- protein kinase
- bariatric surgery
- metabolic syndrome
- phase ii study
- weight gain
- poor prognosis
- cell proliferation
- blood glucose
- polycystic ovary syndrome
- adipose tissue
- signaling pathway
- open label
- physical activity
- obese patients
- cell wall
- transcription factor
- genome wide
- bone mineral density
- long non coding rna
- blood pressure
- oxidative stress
- risk assessment
- pregnant women
- dna methylation
- pregnancy outcomes
- body mass index