Effect of linagliptin on pulse wave velocity in early type 2 diabetes: A randomized, double-blind, controlled 26-week trial (RELEASE).
Stefanie A de BoerHiddo J Lambers HeerspinkLuis E Juárez OrozcoArie M van RoonPieter W KamphuisenAndries J SmitRiemer H J A SlartJoop D LefrandtDouwe J MulderPublished in: Diabetes, obesity & metabolism (2017)
Linagliptin decreased aortic PWV in people with early-stage type 2 diabetes as compared with placebo after 26 weeks of treatment. These results suggest that linagliptin has a favourable effect on arterial stiffness.
Keyphrases
- type diabetes
- phase iii
- early stage
- double blind
- placebo controlled
- clinical trial
- blood pressure
- glycemic control
- study protocol
- phase ii
- cardiovascular disease
- insulin resistance
- open label
- left ventricular
- pulmonary artery
- blood flow
- randomized controlled trial
- adipose tissue
- radiation therapy
- squamous cell carcinoma
- preterm birth
- gestational age
- pulmonary hypertension
- pulmonary arterial hypertension
- neoadjuvant chemotherapy