Analysis of SIRT4 gene single-nucleotide polymorphisms in a Han Chinese population with dilated cardiomyopathy.
Yue ZhongCan ShenYing PengKai LiQin LiYaping SongBin ZhouLi RaoPublished in: Biomarkers in medicine (2021)
Aim: We aimed to investigate the association of SIRT4 gene polymorphisms with the susceptibility and prognosis of dilated cardiomyopathy (DCM) in a Chinese population. Materials & methods: A total of 369 controls and 373 DCM patients were enrolled. Three tag single-nucleotide polymorphisms (rs2261612, rs2522138 and rs16950058) on SIRT4 were evaluated. Results: G carriers of rs2261612 were associated with the susceptibility of DCM in codominant, dominant and overdominant genetic models (all p < 0.01). Furthermore, the AG/GG and AG genotype of rs2261612 in dominant and overdominant models correlated with poor prognosis of DCM, independent of left ventricular ejection fraction and cardiac resynchronization therapy (p < 0.001). Conclusion: SIRT4 polymorphisms were associated with the susceptibility and prognosis of DCM in a Chinese population.
Keyphrases
- ejection fraction
- poor prognosis
- aortic stenosis
- left ventricular
- cardiac resynchronization therapy
- oxidative stress
- ischemia reperfusion injury
- heart failure
- long non coding rna
- quantum dots
- genome wide
- copy number
- acute myocardial infarction
- prognostic factors
- mitral valve
- aortic valve
- transcription factor
- left atrial