Evaluation of FGFR targeting in breast cancer through interrogation of patient-derived models.

Nicole J ChewTerry C C Lim Kam SianElizabeth V NguyenSung-Young ShinJessica YangMun N HuiNiantao DengCatriona A McLeanAlana L WelmElgene LimPeter GregoryTim NottleTali LangMelissa VerekerGary RichardsonGenevieve KerrDiana MicatiThierry JardéHelen E AbudRachel S LeeAlex SwarbrickRoger J Daly

Published in: Breast cancer research : BCR (2021)

This work highlights how patient-derived models of human breast cancer provide powerful platforms for therapeutic target identification and analysis of drug action, and also the potential of specific FGFRs, including FGFR4, as targets for precision treatment.

Keyphrases

endothelial cells
induced pluripotent stem cells
pluripotent stem cells
risk assessment
human health
replacement therapy