Different Expression of Duodenal Genes Related to Insulin Resistance Between Nonobese Women and Those with Severe Obesity.
Ailec Ho-PlagaroConcepción Santiago-FernandezCristina Rodríguez-DíazCarlos Lopez-GómezSara Garcia-SerranoFrancisca Rodríguez-PachecoSergio ValdesAlberto Rodríguez-CañeteGuillermo Alcaín-MartínezNatalia Ruiz-SantanaLuis Vázquez-PedreñoEduardo Garcia-FuentesPublished in: Obesity (Silver Spring, Md.) (2020)
Independent of BMI, higher insulin resistance was associated with a downregulation of duodenal DEGs mainly related to the immune system, inflammation, and xenobiotic metabolism. Also, intestinal lipoprotein metabolism may have a certain relevance in the regulation of insulin resistance in nonobese women.
Keyphrases
- insulin resistance
- polycystic ovary syndrome
- metabolic syndrome
- adipose tissue
- high fat diet
- high fat diet induced
- type diabetes
- skeletal muscle
- poor prognosis
- body mass index
- pregnancy outcomes
- weight gain
- cell proliferation
- genome wide
- weight loss
- signaling pathway
- gene expression
- early onset
- breast cancer risk
- drug induced
- cervical cancer screening
- transcription factor
- glycemic control
- long non coding rna
- low density lipoprotein